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Acebutolol Side Effects

Acebutolol is used for the treatment of arrhythmias and high blood pressure. Acebutolol Side Effects are sour taste, acidity, bloating, loose stool, upset abdomen, heartburn etc.

Minor Side effects of Acebutolol

  1. Gas or bloating
  2. Acidity
  3. Belching
  4. Loose stool
  5. Abnormal bowel movements
  6. Sadness feeling
  7. Heartburn
  8. Irritability
  9. Indigestion
  10. Loss of appetite
  11. Joints pain
  12. Increased urinary output
  13. Insomnia or trouble sleeping
  14. Tiredness

Serious Side effects of Acebutolol

  1. Pain in chest
  2. Vision loss or changes in eyesight
  3. Trouble breathing
  4. Wheezing
  5. Chest congestion
  6. Swelling of hands and feets
  7. Swellings of face

Contact your healthcare provider if above serious symptoms appear after taking acebutolol.

Side effects of Acebutolol in Detail

The side effects acebutolol include:

Cardiovascular system

Acebutolol may cause severe bradycardia due to its blockade of sympathetic stimulation of β1- receptors on the heart, which permits unopposed parasympathetic activity to decrease heart rate.  The other side effects in the cardiovascular system include syncope, chest pain, worsening of heart block and worsening of congestive cardiac failure.  All the cardiovascular side effects occur because of the sympathomimetic activity of acebutolol.  Hypotension may be caused due to its negative inotropic and chronotropic effects.  Acebutolol must not be administered to patients with severe bradycardia or patients in cardiac shock.  Patients on acebutolol must be warned from discontinuing the therapy abruptly, this may cause severe cardiac reactions.  The drug must be tapered over 2 weeks.  The patient must also be taught how to assess pulse and blood pressure, so that he /she can notify the prescriber immediately in case of any side effects.

Nervous system

Insomnia, fatigue, dizziness, mental changes are the most common side effects observed with use of acebutolol.  The other less reported side effects include memory loss, hallucinations, depression, lethargy, strange dreams, headache, and catatonia.  The patient must be advised not to engage in hazardous activities like driving or handling heavy machinery.

Sensory system

Sore throat, dry eyes, and burning sensation of eyes have been noted.

Endocrine system

Increased hypoglycemic response to insulin has been observed with the use of acebutolol.  Acebutolol may mask the premonitory symptoms of hypoglycemia in diabetic patients or patients treated with insulin.

Gastro intestinal system

The gastrointestinal side effects are nausea, diarrhea, vomiting, mesenteric arterial thrombosis, ischemic colitis, and flatulence.

Hematologic

Thrombocytopenia, Agranulocytosis, and purpura have been identified in patients receiving acebutolol.

Immunologic

Symptoms of immunologic side effects include arthralgia, myalgia, rash, and joint swelling.  Development of lupus syndrome and antinuclear antibodies are observed with use of acebutolol.

Hepatic

Hepatotoxicity is reported by patients on acebutolol.  The symptoms include fever, nausea, headache, and dark urine.  The hepatotoxicity is reversed on discontinuation of the therapy.  Case studies have revealed inflammatory infiltrates in the lever suggestive of immune mediated mechanism.

Integumentary system

Rash, pruritus, dry skin, and sweating are observed in patients taking acebutolol.  The mechanism for hyperhidrosis or sweating is uncertain but is believed to be because of imbalance between the beta- and alpha-adrenergic activities.

Genito urinary system

The side effects in genitourinary system include decreased libido, impotence, Peyronie’s disease, dysuria, nocturia, and frequent urination.  Possible mechanisms by which atenolol effects sexual function is by increasing alpha – sympathetic tone, central nervous system mediated sedation and depression and decreased CNS sympathetic outflow.  The mechanism of Peyronie’s disease remains unclear but has been reported in case studies.

Respiratory system

Fibrotic granulomas and pleural thickening have been observed in patients taking acebutolol.  Respiratory symptoms although rare include rhinitis, dyspnea, wheezing, pharyngitis, and cough.

Hypersensitivity

Hypersensitivity reactions involving acebutolol is rare.  Reports of hepatitis and lymphocytic pneumonitis have been documented with the use of acebutolol.

Musculoskeletal system

Joint pain and cramping may occur due to acebutolol.  The Musculo skeletal symptoms are thought to be because of the beta 2 – partial agonist effect.

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