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Aceclofenac Side Effects

Aceclofenac is used for relieving pain and acts as anti-inflammatory. Aceclofenac side effects are nausea, burning sensation, abdominal pain, diarrhea, headache, dizziness, skin rashes and flatulence.

Minor side effects of aceclofenac

  1. Nausea
  2. Burning sensation in abdomen or heartburn
  3. Abdominal pain
  4. Diarrhea
  5. Headache
  6. Dizziness
  7. Skin rashes
  8. Flatulence
  9. Feeling of sickness
  10. Indigestion
  11. Dizziness

Serious Side effects of aceclofenac

  1. Bleeding on stool
  2. Black tarry stools
  3. Severe allergic reaction or anaphylactic shock
  4. Kidney failure
  5. Swelling of face
  6. Wheezing
  7. Severe abdominal pain
  8. Myocardial infarction

Side effects of aceclofenac in Detail

The side effects of aceclofenac include

Gastrointestinal system

Aceclofenac may cause heart burn, epigastric pain, dyspepsia, diarrhea, nausea, stomach ache, cramps, indigestion, constipation, gastritis, flatulence, mouth ulcers, vomiting, and melena.  Gastrointestinal ulceration and bleeding have been observed by the use of aceclofenac.  Due to the inhibition of COX-1, the prostaglandin activity, which is responsible for maintaining the integrity of the gastric mucosa, is impaired.  This inhibition causes gastric mucosal damage.  Aceclofenac must be used with caution in patients with peptic ulcer disease and, gastro intestinal bleeding or abdominal pain.  The gastro intestinal symptoms can be minimized by reducing the duration and dose of aceclofenac and adding a proton pump inhibitor such as pantoprazole or omeprazole.  It is preferable to administer aceclofenac with or after food to reduce the gastro intestinal symptoms.  Advise the patient to swallow the tablet with a full glass of water and to avoid chewing or crushing the tablet.

Cardiovascular system

The cardiovascular side effects are believed to be caused by COX-2 inhibitory effects on vascular function.  Increased blood pressure, palpitations, hot flushes, vacuities, and myocardial infarction are observed in some cases although rarely.  Aceclofenac must be used with caution in patients who have had previous stroke or myocardial infarction.

Renal system

Side effects may occur in patients with preexisting renal conditions.  Fluid retention and diminished sodium excretion by aceclofenac may lead to azotemia, oliguria, and renal failure.  Patients with inadequate renal perfusion due to congestive heart failure, cirrhosis, dehydration, advanced age rely on prostaglandins to serve as important regulators of  renal blood flow and the use of aceclofenac may increase the chance of renal toxicity due its action of interfering with prostaglandin functioning.


Hepatic side effects of aceclofenac include hepato toxicity, jaundice, elevated transaminases, increased AST and ALT and sometimes eosinophilia.  The mechanisms involved in liver injury are hypersensitivity and metabolic aberration .It is also believed that increased concentration of aceclofenac in the hepatobiliary compartment leads to formation of reactive metabolites that produce oxidative stress and mitochondrial injury leading to hepato toxicity. Patients must be advised to refrain from taking over the counter medications or herbal supplements without consulting the prescriber.

Integumentary system

Erythema, itching, skin rashes, and photosensitivity skin reactions may occur with the use of aceclofenac.  Allergic contact dermatitis, generalized pustular psoriasis, precipitation of porphyria and Stevens Johnson syndrome have also been reported with the use of aceclofenac.

Respiratory system

Aceclofenac may cause bronchospasm, stridor, and dyspnea.  Respiratory side effects are usually observed with hypersensitivity reactions.

Nervous system

Aceclofenac may cause side effects like tingling sensations, tremors, headache, drowsiness, vertigo, hallucinations, insomnia, tinnitus, and confusion.  Meningitis like symptoms that include fever, disorientation, and stiff neck has been reported in patients taking aceclofenac.  The mechanism by which aceclofenac causes side effects of the nervous system remains unclear.  Advise patient to avoid hazardous activities like driving or handling heavy machinery.

Hematologic system

The side effects in hematologic system are very rare; they include anemia, thrombocytopenia, and depression of bone marrow function.


Hypersensitivity reactions of aceclofenac are reported.  These are characterized by multiple purpuric lesions, and reduced renal function.

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